Kale

I’m a mech E in the medical field. We’re consistently understaffed. If I validate an Excel worksheet in Excel '08 or a Python program in 3.5 with a specific version of NumPy, we’re probably sticking with those versions for a while. Every time I bring up re-validating with the latest version, keeping one old system running the old software requires fewer resources than me or a colleague re-validating.

My whole department is stuck on one version of Python because that was the most recent version when I had an emergency project and developed a data analysis algorithm. We validated it, then as new members were added to my team, they needed a copy, so we had to keep using it. I’ll probably re-validate it to the next Python release. It’s not only unit tests, or we could automate validation. Unit tests are a tiny part of validating software for making medical decisions. And software that directly runs a medical device (like firmware on an insulin pump) is an order of magnitude more rigorous than what I do.

Side note: there are people who somehow root their insulin pumps and run algorithms on them. There’s a group that can get a PID control loop on an insulin pump that has a more simple control scheme on it (because that’s how the FDA approved it). The company has been trying to get approval to use PID control in the US for years.

I love MPFC, but some of the sketches are “meh”. For every “Battle of Pearl Harbor”, there’s a “Confuse-a-cat”.

Fawlty Towers is great. Mildly racist against the Spanish and Irish.

It takes 4 episodes to really build into the complexity. Then season 2 turns it on its head.

Red Dwarf is pretty good. Fawlty Towers is great. Someone recommended “Yes Minister” and the first season is awesome. The Hallmark of great comedy writing is if it holds up, and Yes Minister still is hilarious 40 years later.

Dark is a German Netflix show. It unfolds into something akin to “Lost” over the first four episodes. The ending doesn’t suck, and they set up the end to where it’s almost impossible to get it right. It’s not an amazing ending, but it’s impressive that they managed to make it not terrible, since it builds up to a near-impossible ending.

Squid Game is pretty great but gory. Letterkenny and Trailer Park Boys are quirky comedies with some rough language throughout.

Seriously? I was looking at a Surface product recently, and it appeared to have an access panel for the NVME drive. I read a ton of complaints about the dimensions of the drive being unusual, but access to it was easy. I don’t think I was looking at a Surface pro though.

If a surface pro wants to be a full OS and not a tablet OS, it should be easy to replace the storage device.

You should be as loyal to your company as your company is to you.

His childhood primed him for comedy.

I haven’t dealt with HPC in a while, but Intel C compiler against MKL libraries were fastest CPU, and Nvidia CUDA was slightly easier to develop than OpenCL for other cards. I’m not sure if the situation’s changed.

For my current applications, I use NumPy compiled against Intel MKV installed as a binary. It works great.

Oof. Is that the official plugin language? Siemens NX uses “grip” which is a fork of TCL. And they require purchase of a pricy package to sign and compile code so NX will run it, so we only had one programmer for our custom grip functions.

Reverse Polish notation, right? Operand operand operator?

Relationships take effort and luck. You have to work on yourself to be prepared, put a lot out of effort into social things to meet people and develop relationships, and then most don’t work out and you’re sad for a bit.

The luck part is a huge part of the equation. Two people are perfect on paper but the “spark” doesn’t happen. Maybe they could have a great relationship but the starting conditions weren’t right to form a relationship. Having a close relative die, or having a mental health issue really early in a relationship can force a wedge that can’t be overcome yet. A normal wedge that all relationships deal with regularly once they’re established, but can’t deal with in the first few weeks.

The only advice that worked for me (I was raised with very few other kids my age) when I started dating in college was that the skills to make a romantic relationship were just people skills. That I should intentionally strike up conversations with anyone I don’t know. Most people have something to occupy their time. I try to find that out in the first conversation I have with someone. You can see when someone’s expression changes when the ice breaks and they shift into excitedly talking about a new personal best in a 10k run, or getting a major part in King Lear, or published their first full comic book or novella.

I had to hone my ability to talk about my hobbies. At the time I was finding gargantuan prime numbers. I had to work on how to describe it to people to make it slightly approachable.

I also figured out that a huge part of wanting to be in a relationship was family pressure. I had to be at a place where I wanted it, and not because aunts and uncles poked fun at any young single people in the family.

I don’t think a lot of thinking was part of that equation.

“why would we want to marry our cousins?”

“because they’re so attractive?”

I don’t have a refined palette, and I like fairly hoppy beers. It has to have a good flavor to it though. If it’s made hoppy for the sake of IBUs, then it’s probably bad. Like joke hot sauces are disgusting, but there are some that are delicious but really painful for me to eat, even one bite.

Older IPA hops like cascade are great but only slightly hop heavy with their classic hop flavors. The hops used more recently (I think citra and mosaic?) have great flavors when pushed to high IBUs.

Hops have amazing range. Fuggles smell like dirt. Lemondrop has a strong citrus smell.

About half of beer variety is from hops. Unless your talking about Belgians. Then it’s all yeast.

A decade ago I had a little extra money and chose to buy a 144 hz gaming monitor and video card. I don’t have great eyesight nor do I play games that require twitch reflexes, but at that time 144 hz frame rate (and configuring the game to be >100 fps) was very noticable. I’d much rather play 1080 at >100 fps rather than 4k at 60 fps or below.

This may be different between people. I don’t believe I have great eyesight, depth perception, color perception, etc, but I am really sensitive to motion. I built my second computer (AMD Athlon 64 bit I think?) and spend a significant sum on a CRT that had higher refresh rates. I can’t use a CRT at 60Hz. I perceive the flicker and I get a headache after about 20 minutes. I couldn’t use Linux on that computer (I was stuck at 60 hz on that kernel/video driver) until I saved up even more to buy an LCD monitor. I can’t perceive a 60 hz flicker on an LCD, and 60Hz is fine for work.

But for gaming, high refresh rate is noticable, even for someone that normally doesn’t notice visual stuff, like me.

Related to fingerprinting, it’s theorized that if a person doesn’t have a Facebook account but their friend group does, Facebook will create a “shadow account” which isn’t public but still attempts to collect data for this person based on the posts, pictures, and location data from friends on Facebook that spend time with this person. Zuckerberg admitted to Congress that Facebook does collect information on non-users.

Even for users, Facebook attempts to establish a lot of metrics, even if the user doesn’t provide them, like estimated income and political affiliation, for advertisers to use.

I saw some of this first hand. Several years ago I tried some advertising for some affiliate marketing. Facebook’s ad platform let me limit advertising to people with gaming consoles between certain ages, and I noticed I could target it for people who likely leaned more liberal or conservative if I wanted, or only for an estimated household income level. It’s surprisingly detailed.

*she’s unable to relocate

Have you been playing Starfield? This is related to something in the game.

It has a small function. A random gamma ray decides to absorb into DNA? Well, 85% chance it won’t matter.

My understanding is that on average a human will make malignant cell about once a year, but the other anti-cancer systems of the body deal with it. People that develop cancer had one of those cells escape the system. Without introns this would be a much more frequent event.

Similar idea: at work we were sintering metal powders together in a vacuum chamber, but had oxygen diffuse into the metal about twice as much as our limit to keep it strong. So the lead researcher took titanium powder that weighed a little more than twice what our work part weighed and put it in the chamber, and the oxygen level dropped to about half in our parts. After that he started making three parts at a time to keep oxygen levels down.

It’s not a reason for developing this way, but introns are great for familial testing. They don’t need to be preserved so they’re changing all the time. If we didn’t have introns, familial testing would have to be done by looking at several DNA or protein types. Blood type, what D2 receptor phenotype. What MTHFR phenotype, etc.

Sorry for long post but I love this topic: in all primates non-coding DNA, there’s the gene that makes vitamin C. Most mammals make their own, except primates and Guinea pigs. In primates, the vitamin C gene is broken at the same location. So, the chances of multiple species of primates developing this mutation at the same place is very low. They’d all have to develop this mutation at the same place and thrive over the other members of the species, and become the dominant phenotype, and all offspring consume enough vitamin C in their diet to thrive also. Every single primate!

Instead, it’s much more plausible that one primate or primate ancestor develop this mutation in an area where the food sources had plenty of vitamin C, and a population reduction caused this ancestor primate to be the sole ancestor of the remaining primates, which then evolved to become monkeys, apes, and humans.

The Guinea pig vitamin C mutation that causes it to not work? It’s in a different location than the primate mutation.

Edit: apparently some primates can make vitamin C. But most can’t, and the ones the can’t, the gene is broken at the same place.

If an embryo decides to split in two, and then sends out the marker that “this is the right side” and it’s too close to the other embro, there will be a set of identical twins, but one will have the heart on the right side, appendix on the opposite side etc. This needs to be known if the “mirrored” person has a colonoscopy, since the colon is folded the opposite direction.