So long as you can run Docker, I would think that you could setup an instance. You just need to make sure that the image you use for lemmy and lemmy-ui are compatible with your platform. I had to alter the provided docker-compose.yml file to use arm64 versions for my RaspberryPi.

I mentioned the total disk usage for the sake of setting up a pi. I don’t know what the space requirements are for lemmy.