The answers to both of your questions are probably yes it’s okay, and yes you should probably be looking for another job.
Are you morally/ethically okay with your agency’s mission? With your role in it? If you are, then the new administration’s policies may not be reason enough to leave. You pretty much have to work somewhere. If the answer is no, you probably would have already been looking for another job.
Should you be looking for another job? Probably, depending on what your agency is and it’s mission. If TFG and Project2025 have their way, many federal government agencies will be defunded and/or privatized, and pretty much toothless when it comes to enforcement. We already saw what happened to the EPA under the first Trump administration. If yours is in danger of that you should be preparing a backup plan. I wouldn’t want to give up a government job, but I would want to be ready if I got RIF’d, or if I got fed up with the bullshit.

My cat’s claws will curl around until they are starting to dig into her toe pads.

All of my machine names are related to Elvis Presley. Elvis has been my desktop PC for years, and I have or have had Priscilla, Lisa-Marie, ColonelParker, Blue-Hawaii, Hound Dog, Memphis, Tupelo, and Graceland. I want to rethink this a bit to have to flow better, maybe have Graceland as my network name, or maybe the router. Also thinking about changing to something space-related or Norse Mythology as the theme.